Tablet Presentation

Each Film Coated Tablet Contains:
Fenofibrate IP (Micronised) 200 mg

Fenofibrate belongs to the class of fibrates and is used with low fat food or other drugs to reduce the fatty substances such as cholesterol and circulating triglycerides in the blood or to increase the level of HDL (good fat).

Indications

• Primary hypercholesterolemia
• Dyslipidemia
• severe hypertriglyceridemia

Mechanism of action

Fenofibrate activates the PPAR-alpha receptors that further activates the gene transcription and gene translation to produce peroxisomes contains Hydroxyl Radicals , hydrogen peroxide, oxygen reactive species to promote lipolysis.

Pharmacokinetics

Absorption: It is absorbed orally
Protein binding: It is mainly bound to albumin and it is about 99.9% bound to serum proteins
Metabolism: It undergoes hydroxylation and glucuronidation
Excretion: It is excreted via urine

Side Effects

• Stomachache
• Nausea
• Vomiting
• Dark urine
• Yellowing of the eyes
• Weakness

Contraindication

• Contraindicated in the patients with renal impairment
• Contraindicated in patients with liver disease

Storage

Store this drug at room temperature.

Pregnancy: Not recommended to use during pregnancy